It's high noon on Wisteria Lane as a brand-new rival stirs up even more excitement, deceit, and romance in the neighborhood. Lynette gets jealous when Renee starts spending time with Tom, and Bree finds herself falling for Keith. Meanwhile, Gabrielle makes a shocking personal discovery, Susan copes with a life-threatening event, and a mysterious shooting has everyone on edge.

The neighborhood is jolted with the arrival of Angie Bolen and her family, and it soon becomes clear that they are hiding something. But what is their secret, and what are their true intentions? Meanwhile, a plane crash on Wisteria Lane causes everyone to reflect on their lives and the choices that have made them who they are.