Fifteen-year-old Josh has chosen to side neither with his twin sister Sophie nor with the Alchemyst, Nicholas Flamel, but rather to fight alongside Dr. John Dee and the mysterious Virginia Dare, while the immortal Machiavelli and Billy the Kid follow the Elders' plans to set loose the monsters of Alcatraz on San Francisco and trigger the end of the humani race.

"The twins of prophecy have been split. Nicholas Flamel is near death. John Dee has the swords of power. And Danu Talis has yet to fall. The future of the human race lies in the balance--how will the legend end?"--Provided by publisher.

Fifteen-year-old twins, Sophie and Josh, find themselves caught up in the deadly struggle between rival alchemists, Nicholas Flamel and John Dee, over the possession of an ancient book that holds the secret formulas for alchemy and everlasting life.